Telomeres are specialized DNA structures located at the ends of chromosomes, functioning similarly to the plastic tips on shoelaces—preventing the chromosome ends from fraying. These unique structures protect our genetic information during cell division, ensuring that genetic data is accurately passed to new cells. However, telomeres shorten with each cell division, and once they reach a critically short length, cells will stop dividing, a process closely associated with aging, cancer, and other related diseases.
The existence of telomeres was initially revealed in the 1930s through studies on plant and animal cells. In 1978, Elizabeth Blackburn and her colleagues first described the molecular structure of telomeres, opening the door to in-depth studies of their biological functions. Over the subsequent decades, the role of telomeres in cell stability during division, as well as their involvement in aging and cancer, has been increasingly understood.
Telomeres play several key roles in biology:
Telomeres prevent chromosomes from being damaged, ensuring that DNA can be fully replicated during cell division.
The length of telomeres directly impacts the lifespan of a cell. As cells divide more, telomeres shorten and eventually trigger mechanisms of cellular aging or death.
Abnormal shortening of telomeres is associated with the development of various diseases, including cardiovascular diseases, certain types of cancer, and genetic disorders.
Research on telomeres not only focuses on how they influence cell aging but also on their role in the onset and progression of diseases. Studies have shown that abnormal shortening of telomeres may accelerate the development of certain diseases, while maintaining telomere stability helps preserve cell function and delay the aging process.
Current and future research on telomeres is focused on understanding how telomeres regulate cell fate and their specific roles in diseases. This research not only provides new insights into cellular aging but could also guide the development of therapeutic strategies for related diseases in the future.
Telomere and telomere-related mechanism research remains a hot topic in biomedical studies, continuously advancing our understanding of life processes. The outcomes are crucial for the future of biomedicine and the development of new therapeutic approaches.
References:
1/
Greider, C. W., & Blackburn, E. H. (1985). Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell, 43(2), 405-413.
2/
Blackburn, E. H., Greider, C. W., Henderson, E., Lee, M. S., Shampay, J., & Shippen-Lentz, D. (1989). Recognition and elongation of telomeres by telomerase. Genome, 31(2), 553-560. https://doi.org/10.1139/g89-104
3/
Blackburn, E. H. (1984). Telomeres: do the ends justify the means? Cell, 37(1), 7-8. https://doi.org/10.1016/0092-8674(84)90295-2
4/
Blackburn, E. H. (1994). Telomeres: No end in sight. Cell, 77(5), 621-623.https://doi.org/10.1016/0092-8674(94)90046-9
5/
Blackburn, E. H. (1991). Telomeres. Trends in Biochemical Sciences, 16(10), 378-381. https://doi.org/10.1016/0968-0004(91)90155-o
6/
Blackburn, E. H. (1984). The molecular structure of centromeres and telomeres. Annual Review of Biochemistry, 53, 163-194. https://doi.org/10.1146/annurev.bi.53.070184.001115
7/
Blackburn, E. H. (1991). Structure and function of telomeres. Nature, 350(6319), 569-573. https://doi.org/10.1038/350569a0
8/
Szostak, J. W., & Blackburn, E. H. (1982). Cloning yeast telomeres on linear plasmid vectors. Cell, 29(1), 245-255. https://doi.org/10.1016/0092-8674(82)90109-x
9/
Greider, C. W., & Blackburn, E. H. (1989). A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature, 337(6205), 331-337. https://doi.org/10.1038/337331a0
10/
Shammas, M. A. (2011). Telomeres, lifestyle, cancer, and aging. Current Opinion in Clinical Nutrition and Metabolic Care, 14(1), 28–34. https://doi.org/10.1097/MCO.0b013e32834121b1
11/
Verma, A. K., Singh, P., Al-Saeed, F. A., Ahmed, A. E., Kumar, S., Kumar, A., Dev, K., & Dohare, R. (2022). Unravelling the role of telomere shortening with ageing and their potential association with diabetes, cancer, and related lifestyle factors. Tissue and Cell, 79, 101925. https://doi.org/10.1016/j.tice.2022.101925
12/
Creighton, H. B., & McClintock, B. (1931). A Correlation of Cytological and Genetical Crossing-Over in Zea Mays. Proceedings of the National Academy of Sciences of the United States of America, 17(8), 492–497. https://doi.org/10.1073/pnas.17.8.492
13/
McClintock, B. (1931). The order of the genes C, Sh and Wx in Zea Mays with reference to a cytologically known point in the chromosome. Proceedings of the National Academy of Sciences of the United States of America, 17(8), 485–491. https://doi.org/10.1073/pnas.17.8.485
14/
McClintock, B. (1934). The relation of a particular chromosomal element to the development of the nucleoli in Zea mays. Zeitschrift für Zellforschung und Mikroskopische Anatomie, 21(2), 294-326.
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